Introduction Colorectal carcinoma (CRC) is one of the major causes of cancer mortality but there are a lack of reliable biomarkers to predict tumour progression and prognosis. KCNJ14 is a member of the inwardly rectifying...
Introduction Dai et al (2025) deployed a multi-faceted approach to investigate the mechanisms controlling Latent Endometrial Tuberculosis (LETB). LETB damages endometrial structure and function, undermining implantation and increasing infertility risk. LETB can be asymptomatic and...
Introduction Crohn’s disease (CD) is characterised by relapsing inflammation that recurs in the same regional locations within the intestine. This suggests that permanent or long-lasting, molecular changes are occurring at the cellular level. Epigenetic modifications...
Introduction Alopecia areata (AA) is the most common inflammatory hair disease. Current therapies do not suppress disease reoccurance. Interferon gamma (IFNg) is a key pathogenic cytokine that drives AA. Interleukin 15 (IL-15) can activate IFNg...
Introduction N-acetyltransferase2 (NAT2) is a phase II drug metabolic enzyme with many reported SNPs that affect its catalytic activity. Depending upon the combination of alleles present a subject could have slow, intermediate or rapid acetylator...
Introduction Regulation of cell proliferation, differentiation and death in the intestinal epithelium has been the focus of intense research for many years. In addition to epithelial-intrinsic factors, the roles of the mucosal immune system, enteric...
Introduction The intestinal epithelium forms a selective barrier that facilitates nutrient absorption while blocking harmful substances and pathogens. Disruption of this barrier contributes to gastrointestinal diseases such as IBD and infections. While the roles of...
Introduction TIFA was first identified more than 20 years ago as a binding protein for TRAF2/6, playing a role in pro-inflammatory signalling pathways. More recently, it has been shown to be essential for signalling by...
Introduction Breast cancer survival rates have improved over the decades, but one-third of diagnoses still result in death. Therefore, identifying novel molecular targets is crucial. Hypoxia, common in breast tumors, is linked to tumor progression,...
Introduction The gut microbiota is now recognised as a central player in the pathogenesis and progression of inflammatory bowel disease (IBD). In their recent study, Wang et al examine how disruptions in microbial composition can...
