Messenger RNA (mRNA)‑based therapeutics confer less risk due to the transient nature of expression and with the success of the COVID‑19 vaccinations, a greater confidence in their safety has resulted in more therapies progressing to...
Kidney fibrosis is the hallmark of chronic kidney disease (CKD) progression; however, no current antifibrotic therapies exist due to the intricate cellular mechanisms involved in fibrosis and the origin of scar-forming cells in human kidney...
Gastric cancer is the fifth most common cancer worldwide and remains the third most common in cancer-related deaths, despite a declining incidence rate in recent years. A lack of screening means that gastric cancer patients...
Introduction Pulmonary fibrosis is a serious lung disease characterised by the spontaneous buildup of scar tissue in the absence of infectious or autoimmune diseases. It has a poor prognosis, with a 50% three-year survival rate,...
Advancing Radiation Research: Insights from Non-Human Primate Models on Delayed Effects of Acute Radiation Exposure The acute physiological effects of irradiation in multiple organs have been well characterised in small animal models, particularly mice. To-date...
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissue in culture to study tissue biology and their use for biomedical applications. Liver organoids have now been established for multiple species from induced pluripotent...
Non-small-cell lung cancer (NSCLC) makes up for ~85% of lung cancer patients, which is the most frequent cause of cancer-related death worldwide. Although, new targeted therapies and personalised medicine have improved outcome, most patients eventually...
The intestinal epithelium is characterised by intense self-renewal which is accomplished by intestinal stem cells (ISCs), located at the base of the crypts. Beyond normal tissue homeostasis, these cells play a major role in the...
Inflammatory bowel disease (IBD) is a group of debilitating gastrointestinal (GI) disorders characterized by epithelial damage and chronic inflammation. Epithelial targeting aimed to repair and protect the epithelial barrier is central to current clinical practice....
The basis of maintaining a healthy gut is the tripartite communication between the intestinal epithelium, the mucosal immune system, and the intestinal microbiome. It is important to maintain conditions that allow appropriate responses by the...
