Anti-Cancer Drug Development Platform
In Vitro and In Vivo Human Angiogenesis Assays
In Vitro Assay to Assess Cancer Stem Cell Targeting Agents
In Vitro Oncology Models for Preclinical Screening
In Vivo Orthotopic and Metastatic Models for More Accurate Representation of Clinical Disease
Epithelial Tumour Xenograft Services
Aetiology, Mechanism and Prevention of Epithelial Toxicity
Off Target / Off Tissue Side Effects
Mucositis Drug Discovery Platform
Acute Radiation Syndrome (ARS) & Delayed Effects of Acute Radiation Exposure (DEARE)
Predictive In Vitro Screening to Guide Preclinical Development of Novel Molecules
Predictive In Vitro Screening to Guide Preclinical Development of Novel Drugs
In Vivo Inflammatory Bowel Disease models
3D Human Skin Models and Monolayer Culture
Preclinical Models of Wound Healing
An integrated component of an in-house study package or as a stand-alone service
Gene Expression Analysis of Isolated Cell Populations
Gene and Protein Expression in Single Scalp Hairs
Reproducible Gene Expression Profiles from Plucked Hair
Global and Focused mRNA and miRNA Profiling Services
Rapid DNA sequencing technology for genomic analysis
Specialised Analysis of Target Genes
A Key Mediator of Gene Expression
Histology and Immunohistochemistry Services
Long-Term Experience of Using Anti-IL-12/23 p40 IgG as a Reference Therapeutic in Adoptive T Cell Transfer Models of Colitis.
Monitoring Microbial Diversity in Healthy Volunteers Using 16S Metagenomic Sequencing.
The Use of Intestinal Organoids as a Preclinical Screen to Assess Gastrointestinal (GI) Toxicity and Barrier Integrity.
Evaluation of Drug Target Engagement on Pharmacodynamic Biomarkers in Human Plucked Scalp Hair.
The use of intestinal organoids as a preclinical screen to assess gastrointestinal (GI) toxicity and barrier integrity.
Evaluation of drug target engagement on pharmacodynamic biomarkers in human plucked scalp hair.
Small intestinal organoids to study the effects of tight junction modulators that may improve the absorption of orally administered, anti-neoplastic drugs.
Pharmacodynamic Biomarkers: Evaluation of oncology drug target engagement in human plucked scalp and beard hair
Identification of a gene signature that predicts gastrointestinal-toxicity induction in small intestinal organoids
Characterization of infiltrating immune cells after irradiation using 10x genomics single cell sequencing
Animal models of prostate cancer
Plucked anagen scalp hair: A comparison between different analytical techniques to establish reproducible drug induced transcriptional changes and provide pharmacodynamic biomarker and target engagement information from oncology patients
Identification of a gastrointestinal (GI) toxicity gene signature from common chemotherapeutic agents using organoids and GI-tissue
Long-term experience of using anti-IL-12/23 p40 IgG as a reference therapeutic in adoptive T cell transfer models of colitis
Establishment and Maintenance of Mouse Hepatic Progenitor Organoids for In Vitro Evaluation of Antifibrotic Drugs
Valid until October 2025