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Laser Capture Microdissection

Leveraging Epistem’s Experience Deriving Data From Very Limited Quantities of RNA

Laser Capture Microdissection (LCM) is a powerful technology that enables the isolation of specific cell populations from tissue sections, making it a valuable tool for gene expression analysis, biomarker discovery and genotyping.

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Leveraging the Power of LCM for Gene Expression

Epistem has developed highly sensitive proprietary techniques for analysing formalin-fixed, paraffin-embedded (FFPE) and fresh frozen samples using LCM. Our team of experts offer gene expression analysis services for both sample types, guiding customers in planning LCM studies to ensure optimal gene expression profiling.

Epistem has experience in various tissues such as lung, liver, and kidney, identifying key pathways and regulators by comparing disease foci with normal comparator regions.

We have assessed multiple clinical cohorts to understand inter-foci and inter-patient variation, as well as the underlying disease biology.

Our high-throughput LCM capabilities generate rich and deep transcriptional datasets, facilitating the validation or invalidation of target pathways in drug development programs.

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