Skip to content

Orthotopic and Metastatic Bioluminescent Models

Advanced Models of Disease Using Imaging to Monitor Growth and Metastasis

Our bioluminescent imaging capabilities enable non-invasive longitudinal monitoring of disease progression and response to novel therapeutic agents to help support drug development. All our models are fully complemented by our range of in vitro and ex vivo assays, as well as our comprehensive flow cytometry, histology and biomarker analytical services. Our team of experts can help customers design and execute preclinical studies, enabling them to make informed decisions about the development of potential therapeutics for the treatment of cancer.

Why Orthotopic and Metastatic Bioluminescent Models?

These models provide a more physiologically relevant platform to evaluate the efficacy of potential cancer treatments, since the tumour is grown within its natural microenvironment within the host tissue, unlike a subcutaneous implant. This may better predict clinical outcome.

Leukaemic and Solid Tumour models are available. Luciferase labelled cells are monitored longitudinally using imaging to provide tumour progression data.

Orthotopic Models

Cells are grown within the relevant body site, such as in the blood/bone marrow for leukaemia models (acute myeloid leukaemia and acute lymphocytic leukaemia) and the lung for lung cancer models.

Bespoke Services

In addition, we offer a bespoke service for new model development where we can luciferase-tag the cell line of your choice for future in vivo use.

Metastatic Models

These models can be used to evaluate the efficacy of a drug on metastatic invasion and/or established metastatic lesions in secondary organs. Metastasis can occur via natural spread or be modelled by direct implantation into the metastatic site. For example, our ovarian cancer model is implanted into the intraperitoneal cavity, and the prostate cancer model can be implanted directly into the femur or intravenously to form liver metastases.

Download the latest brochure

From brochures to posters, find all the information you need in a downloadable & printable format.

Contact information

For more information regarding our services, please do not hesitate to contact us.

Contact us