Our oncology team has a wealth of experience taking therapeutic agents from early-stage in vitro proof of concept testing, in vivo efficacy models, through to quantification of target engagement (biomarkers) that are then used to support clinical studies. Services are offered individually or as part of an integrated package.
Target validation includes cell line / cancer stem cell and grafted tumour responses, pre and post exposure target expression levels and induced pathway responses. In vivo models may be simple subcutaneous models or more complex orthotopic/metastatic models employing bioluminescent tumour cells and imaging techniques. Treatments may be small molecules, antibodies (+/- a payload), cell therapies, radiation (+/- radiosensitisers) and combinations of the above.
- Target Validation
- Cancer Stem Cell Sphere Assay
- Subcutaneous Xenograft Model
- Therapy Side Effects
- Orthotopic & Metastatic Bioluminescent Models