Gene expression can be of particular advantage where the target or pathway is unknown or there is not a suitable antibody available that allows responses to be measured easily. Many gene changes can be measured simultaneously with low intra- and inter-donor variation. Unlike IHC a single protocol is suited to all applications.
Epistem’s extensive database containing gene expression profiling information from mouse, rat and human samples can confirm if genes of interest are expressed in hair. Ex vivo exposure of hair to a drug allows drug-related changes in gene expression to be established and a potential gene signature generated.