Introduction In this article, the authors highlight the importance of miRNAs and present the existing evidence of their relationship with lung cancer. miRNA molecules regulate gene expression and play a critical role not only as...
Introduction Crohn’s disease (CD) is a chronic condition characterised by intestinal inflammation that progressively leads to bowel destruction involving fistulas and stricturing fibrosis, along with other extra-intestinal complications. Disease triggers are likely to be multifactorial,...
Introduction Androgenetic alopecia (AGA) is a genetic condition that affects areas of the scalp. Also known as pattern hair loss, males present with thinning hair in temporal areas that proceeds to the crown (male pattern...
Introduction Nenclares et al (2024) utilise a combinational approach to monitor the effect of chemoradiotherapy (CRT) on peripheral T-Cell receptors (TCR). CRT is a gold standard treatment for HPV-related tumour progression such as that noted...
Introduction Marano et al., describe a method to combine RNAscope with immunohistochemistry to achieve double labelling of perforin transcripts within CD8+ or TcRγδ intraepithelial lymphocytes in small intestine sections of celiac disease patients. One aspect...
Introduction Organoids model important aspects of human physiology and play an important role in drug discovery. However, to date, they have been lacking a tissue-specific immune compartment. The intestinal mucosal immune system is the largest...
Introduction A bitesize review of a recent study by Pierre-Alexandre Vidi et al., 2023 (See reference below), Institut de Cancérologie de l’Ouest (ICO) and Wake Forest University School of Medicine Children are particularly vulnerable to pesticide exposures....
Introduction Chemotherapy relies on a high ratio of toxicity toward cancer cells vs. non-malignant cells. Normal tissues with a high proportion of proliferating cells such as the epithelia of the gut, are most vulnerable toward...
Introduction Development of new therapeutics for chronic inflammatory conditions remains a key focus of pre-clinical and clinical research. In a new publication, scientists from the University of Ljubljana show that an abdominally-implanted, ultrasound-activated cellular device...
Introduction Sande et al. conducted a comprehensive evaluation of the clinical utility of the HRM-based HemeScreen MPN assay as a generic diagnostic approach for Philadelphia-negative myeloproliferative neoplasms (MPNs). The majority of mutations identified in MPNs...
