Introduction Invasive Lobular Carcinoma (ILC) is the second most commonly occurring histological subtype of breast cancers with up to 15% diagnosed. E-cadherin loss has been observed in >85% of ILCs and may be the cause...
Introduction Macrophage dysregulation is implicated in inflammatory bowel disease. In this study, the upregulation of the transcription factor E4BP4 in macrophages reduced colitis severity in mice. RNA-seq and single-cell analyses showed that increased levels of...
Introduction Non-alcoholic steatohepatitis (NASH) is the most recurrent form of chronic liver disease. There are two patterns of NASH; cholestatic (affecting bile ducts, reducing bile flow) and hepatitic, with the cholestatic pattern associated with more...
Introduction Dysregulated immunity in the intestine can result in the establishment of Inflammatory Bowel Disease (i.e. Crohn's disease and Ulcerative Colitis). This, in turn, can increase an individual's cancer risk. Elucidating the homeostatic mechanisms that...
Introduction Natural killer (NK) cells hold great potential for their application in tumor immunotherapy, mainly due to their MHC-unrestricted and pan-specific recognition capabilities. 5-fluorouracil (5FU) is the most effective and commonly used chemotherapeutic drug in...
Introduction Chen et all (2023) present a multi-omics approach characterising mechanisms of advanced Renal Cell Carcinoma (RCC) regulated by the tumour microenvironment (TME). Spatial assessment of the TME in primary and metastatic RCC conducted using...
Introduction Prostate cancer (PCa) is a heterogeneous disease, its recurrence and development of metastasis remain clinical problems. Taghreed et al. (2023) combined scRNAseq and spatial transcriptomic analyses to enhance the understanding of PCa. The data...
Introduction Cancer Immunotherapy holds great promise, but patients with excluded tumours (CD8 T cells accumulate at the tumour–stroma boundary) show increased resistance to check-point blockade compared to patients with inflamed tumours (CD8 T cells infiltrate...
Introduction The loss of epithelial barrier function is a hallmark of IBD. TNFα is considered a key driver of IBD, directly causing barrier disfunction. Although TNFα-neutralizing therapy has been used for decades to treat IBD,...
Introduction A recent paper by Jacobsen et al (2023) presents data comparing whole transcriptome sequencing from fresh, frozen and formalin-fixed paraffin-embedded (FFPE) cardiac tissue. This is to investigate the effect of each storage condition on...
