Introduction Natural killer (NK) cells hold great potential for their application in tumor immunotherapy, mainly due to their MHC-unrestricted and pan-specific recognition capabilities. 5-fluorouracil (5FU) is the most effective and commonly used chemotherapeutic drug in...
Introduction Chen et all (2023) present a multi-omics approach characterising mechanisms of advanced Renal Cell Carcinoma (RCC) regulated by the tumour microenvironment (TME). Spatial assessment of the TME in primary and metastatic RCC conducted using...
Introduction Prostate cancer (PCa) is a heterogeneous disease, its recurrence and development of metastasis remain clinical problems. Taghreed et al. (2023) combined scRNAseq and spatial transcriptomic analyses to enhance the understanding of PCa. The data...
Introduction Cancer Immunotherapy holds great promise, but patients with excluded tumours (CD8 T cells accumulate at the tumour–stroma boundary) show increased resistance to check-point blockade compared to patients with inflamed tumours (CD8 T cells infiltrate...
Introduction The loss of epithelial barrier function is a hallmark of IBD. TNFα is considered a key driver of IBD, directly causing barrier disfunction. Although TNFα-neutralizing therapy has been used for decades to treat IBD,...
Introduction A recent paper by Jacobsen et al (2023) presents data comparing whole transcriptome sequencing from fresh, frozen and formalin-fixed paraffin-embedded (FFPE) cardiac tissue. This is to investigate the effect of each storage condition on...
The epigenetic regulation of immunity and its role in inflammatory disease has become a growing focus of research over the last few years. Much of this work has investigated chromatin modification and its impact on...
Given the highly dynamic state of the environment which gives rise to tumorigenic growth, it is highly desirable to characterise not only the promoters of said growth but to also decipher the genetic conditions required...
Introduction Despite large scale technological and data-driven advances, efficacious and long-lasting treatments for chronic gut illnesses such as IBD, Crohn’s and Ulcerative Colitis (UC) appear to remain out of reach for the millions of sufferers...
Currently uncurable, Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders. Characterised by progressive loss of dopaminergic neurons in the Substantia Nigra area in the brain, PD leads to the development of progressive...
