What We Do

Preclinical Models & Clinical Analytical Platforms

At Epistem, we specialise in advancing drug development and improving patient outcomes. We provide innovative preclinical research models and services to speed up the drug discovery process. Our clinical services include sample analysis, data analysis, and regulatory support. By seamlessly integrating preclinical models with clinical expertise, we expedite the transition of potential drug candidates from preclinical stages to clinical trials, ultimately bringing new treatments to patients faster.

Oncology

Target Validation • Cancer Stem Cell Sphere Assay • Subcutaneous Xenograft Models • Therapy Side Effects • Orthotopic Models

Organoids

Intestinal Organoids • Liver Organoids • Organoid-Derived Monolayer Assays

Inflammatory Bowel Disease

DSS Induced Acute and Chronic Mediated Colitis • Adoptive T-Cell Transfer Mediated Colitis • IL-10 Knockout Spontaneous Colitis • Bespoke Colitis Models

Dermatology

Monolayer Assays • Human Living Skin Equivalent • Organ Culture • Human Skin Xenografts • Psoriasis • Hair Growth • Wound Healing

Immune Cell Assays

Antigen Presenting Cell Assays • T-Cell Assays

GI Toxicity & Mucositis

GI Toxicity Models • In Vivo Mucositis Models

Biodefence

Acute Radiation Syndrome (ARS) Models • Delayed Effects of Acute Radiation Exposure (DEARE) Models

Analytical Platforms & Services

We are committed to advancing drug discovery and development by providing innovative and cutting-edge analytical platforms and services to our clients. Whether it is for individual projects, in conjunction with preclinical research models or clinical services, or as part of a complex therapeutic pipeline, our technologies are designed to accelerate drug development and ultimately improve patient outcomes.

Imaging

Preclinical Imaging • Slide Scanning & Histological Analysis • Image Analysis

Flow Cytometry

Support In-house Models • Analyse Individual Sample Sets

Laser Capture Microdissection

Formalin-fixed, paraffin-embedded (FFPE) Samples • Fresh Frozen Samples

Multiplexed Cytokine Profiling

Standard Screening Panels • Custom-Built Panels

Gene Expression Analysis

Microarray Analysis • qPCR Analysis

Next Generation Sequencing

Whole Genome Sequencing • RNA-Sequencing • Whole Exome Sequencing • TCR-Seq • Targeted Resequencing (Commercially Available Assays and Customised Assays) • Multiple Disease Panels • Microbiome Analysis

DNA Genotyping Analysis

SNP analysis by NGS or Microarrays • Quantitative or Qualitative Analysis by RT-PCR

Metagenomics Analysis

16s rRNA Metagenomics Sequencing • ITS • 16S RNA • Metatranscriptomics

Histology & Immunohistochemistry

Histology • Immunohistochemistry • Image Analysis

Plucked Hair Analysis

Preclinical Plucked Hair Assay • Clinical Plucked Hair Assay • Biomarker Identification, Validation and Screening • Ex Vivo Hair Culture • Hair Immunohistochemistry

DNA Methylation

Reduced Representation Bisulfite Sequencing • Whole Genome Bisulfite Sequencing

Disease and Pathway Panels

Oncology Panels • IBD Panels • Fibrosis Panels • Hair panels

Bioinformatics

Differential Expression • Pathway analysis • Gene Signature Discovery