The relationship between dysbiosis, inflammation and disease is a burgeoning area of research [reviewed in 1-4]. A recently published paper by Sinha and colleagues examines the role of dysbiosis in Ulcerative Colitis[5]. Their work highlights...
Lung cancer causes the most cancer-related deaths worldwide. Lung Adenocarcinoma (LAC), the most prevalent type of non-small cell lung cancer (NSCLC), can occur with various heterogeneity as assessed histologically and can contain acinar, papillary, micropapillary,...
Introduction Coronavirus Disease 2019 (COVID-19) infects host cells through the binding of the spike (S) glycoprotein of the SARS-CoV-2 to ACE2 (angiotensin-converting enzyme 2). Infection of vascular endothelium with SARS-CoV-2 elicits a glycolytic shift and...
The liver connects the intestinal portal vasculature with the general circulation. It consists of hexagonal units called lobules that not only ensure efficient metabolism but also organize immune cells in a strategic topographical distribution. The...
Messenger RNA (mRNA)‑based therapeutics confer less risk due to the transient nature of expression and with the success of the COVID‑19 vaccinations, a greater confidence in their safety has resulted in more therapies progressing to...
Kidney fibrosis is the hallmark of chronic kidney disease (CKD) progression; however, no current antifibrotic therapies exist due to the intricate cellular mechanisms involved in fibrosis and the origin of scar-forming cells in human kidney...
Gastric cancer is the fifth most common cancer worldwide and remains the third most common in cancer-related deaths, despite a declining incidence rate in recent years. A lack of screening means that gastric cancer patients...
Introduction Pulmonary fibrosis is a serious lung disease characterised by the spontaneous buildup of scar tissue in the absence of infectious or autoimmune diseases. It has a poor prognosis, with a 50% three-year survival rate,...
Advancing Radiation Research: Insights from Non-Human Primate Models on Delayed Effects of Acute Radiation Exposure The acute physiological effects of irradiation in multiple organs have been well characterised in small animal models, particularly mice. To-date...
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissue in culture to study tissue biology and their use for biomedical applications. Liver organoids have now been established for multiple species from induced pluripotent...
