The epigenetic regulation of immunity and its role in inflammatory disease has become a growing focus of research over the last few years. Much of this work has investigated chromatin modification and its impact on...
Given the highly dynamic state of the environment which gives rise to tumorigenic growth, it is highly desirable to characterise not only the promoters of said growth but to also decipher the genetic conditions required...
Introduction Despite large scale technological and data-driven advances, efficacious and long-lasting treatments for chronic gut illnesses such as IBD, Crohn’s and Ulcerative Colitis (UC) appear to remain out of reach for the millions of sufferers...
Currently uncurable, Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders. Characterised by progressive loss of dopaminergic neurons in the Substantia Nigra area in the brain, PD leads to the development of progressive...
The relationship between dysbiosis, inflammation and disease is a burgeoning area of research [reviewed in 1-4]. A recently published paper by Sinha and colleagues examines the role of dysbiosis in Ulcerative Colitis[5]. Their work highlights...
Lung cancer causes the most cancer-related deaths worldwide. Lung Adenocarcinoma (LAC), the most prevalent type of non-small cell lung cancer (NSCLC), can occur with various heterogeneity as assessed histologically and can contain acinar, papillary, micropapillary,...
Introduction Coronavirus Disease 2019 (COVID-19) infects host cells through the binding of the spike (S) glycoprotein of the SARS-CoV-2 to ACE2 (angiotensin-converting enzyme 2). Infection of vascular endothelium with SARS-CoV-2 elicits a glycolytic shift and...
The liver connects the intestinal portal vasculature with the general circulation. It consists of hexagonal units called lobules that not only ensure efficient metabolism but also organize immune cells in a strategic topographical distribution. The...
Messenger RNA (mRNA)‑based therapeutics confer less risk due to the transient nature of expression and with the success of the COVID‑19 vaccinations, a greater confidence in their safety has resulted in more therapies progressing to...
Kidney fibrosis is the hallmark of chronic kidney disease (CKD) progression; however, no current antifibrotic therapies exist due to the intricate cellular mechanisms involved in fibrosis and the origin of scar-forming cells in human kidney...
