Introduction Chemotherapy relies on a high ratio of toxicity toward cancer cells vs. non-malignant cells. Normal tissues with a high proportion of proliferating cells such as the epithelia of the gut, are most vulnerable toward...
Introduction Sande et al. conducted a comprehensive evaluation of the clinical utility of the HRM-based HemeScreen MPN assay as a generic diagnostic approach for Philadelphia-negative myeloproliferative neoplasms (MPNs). The majority of mutations identified in MPNs...
Introduction Cancer of unknown primary (CUP) is a rare disease in which malignant cells are present while the originating organ remains unknown. This makes it difficult to treat, as selecting an appropriate therapy is problematic...
Introduction Invasive Lobular Carcinoma (ILC) is the second most commonly occurring histological subtype of breast cancers with up to 15% diagnosed. E-cadherin loss has been observed in >85% of ILCs and may be the cause...
Introduction Natural killer (NK) cells hold great potential for their application in tumor immunotherapy, mainly due to their MHC-unrestricted and pan-specific recognition capabilities. 5-fluorouracil (5FU) is the most effective and commonly used chemotherapeutic drug in...
Introduction Chen et all (2023) present a multi-omics approach characterising mechanisms of advanced Renal Cell Carcinoma (RCC) regulated by the tumour microenvironment (TME). Spatial assessment of the TME in primary and metastatic RCC conducted using...
Introduction Cancer Immunotherapy holds great promise, but patients with excluded tumours (CD8 T cells accumulate at the tumour–stroma boundary) show increased resistance to check-point blockade compared to patients with inflamed tumours (CD8 T cells infiltrate...
Lung cancer causes the most cancer-related deaths worldwide. Lung Adenocarcinoma (LAC), the most prevalent type of non-small cell lung cancer (NSCLC), can occur with various heterogeneity as assessed histologically and can contain acinar, papillary, micropapillary,...
Gastric cancer is the fifth most common cancer worldwide and remains the third most common in cancer-related deaths, despite a declining incidence rate in recent years. A lack of screening means that gastric cancer patients...
Non-small-cell lung cancer (NSCLC) makes up for ~85% of lung cancer patients, which is the most frequent cause of cancer-related death worldwide. Although, new targeted therapies and personalised medicine have improved outcome, most patients eventually...
