Introduction Small cell lung cancers (SCLC) make up approximately 15% of all lung cancers. However, they are one of the most aggressive cancers with a median 5-year survival of about 7%. Typically driven by inactivating...
Introduction Inflammation is a major risk factor for cancer, but the underlying molecular mechanisms remain unclear. There are well-established clinical associations between inflammation in the gut and cancer and patients with ulcerative colitis (UC) are...
Introduction Colorectal cancer (CRC) has a high incidence and high mortality rate, despite surgery and chemotherapeutic treatment options. EGFR-targeted therapies, used to treat RAS WT CRC patients, are still only 55-65% effective suggesting other mechanisms...
Introduction Advanced melanoma remains a highly aggressive malignancy in which immune checkpoint inhibitors (ICIs) have transformed patient outcomes, yet resistance and heterogeneous treatment responses persist. Many clinical assays rely either on tumour informed strategies requiring...
Introduction Colorectal carcinoma (CRC) is one of the major causes of cancer mortality but there are a lack of reliable biomarkers to predict tumour progression and prognosis. KCNJ14 is a member of the inwardly rectifying...
Introduction N-acetyltransferase2 (NAT2) is a phase II drug metabolic enzyme with many reported SNPs that affect its catalytic activity. Depending upon the combination of alleles present a subject could have slow, intermediate or rapid acetylator...
Introduction Breast cancer survival rates have improved over the decades, but one-third of diagnoses still result in death. Therefore, identifying novel molecular targets is crucial. Hypoxia, common in breast tumors, is linked to tumor progression,...
Introduction Caldwell et al., present an approach to the targeted selection of suitable candidate patients into a phase 2 clinical study using a laboratory validated chromogenic RNAscope assay for DKK1. Dickkopf-1 (DKK1), is a secreted...
Introduction In this article, the authors highlight the importance of miRNAs and present the existing evidence of their relationship with lung cancer. miRNA molecules regulate gene expression and play a critical role not only as...
Introduction Nenclares et al (2024) utilise a combinational approach to monitor the effect of chemoradiotherapy (CRT) on peripheral T-Cell receptors (TCR). CRT is a gold standard treatment for HPV-related tumour progression such as that noted...
