Introduction Crohn’s disease (CD) is a chronic condition characterised by intestinal inflammation that progressively leads to bowel destruction involving fistulas and stricturing fibrosis, along with other extra-intestinal complications. Disease triggers are likely to be multifactorial,...
Introduction Organoids model important aspects of human physiology and play an important role in drug discovery. However, to date, they have been lacking a tissue-specific immune compartment. The intestinal mucosal immune system is the largest...
Introduction Chemotherapy relies on a high ratio of toxicity toward cancer cells vs. non-malignant cells. Normal tissues with a high proportion of proliferating cells such as the epithelia of the gut, are most vulnerable toward...
Introduction The loss of epithelial barrier function is a hallmark of IBD. TNFα is considered a key driver of IBD, directly causing barrier disfunction. Although TNFα-neutralizing therapy has been used for decades to treat IBD,...
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissue in culture to study tissue biology and their use for biomedical applications. Liver organoids have now been established for multiple species from induced pluripotent...
Inflammatory bowel disease (IBD) is a group of debilitating gastrointestinal (GI) disorders characterized by epithelial damage and chronic inflammation. Epithelial targeting aimed to repair and protect the epithelial barrier is central to current clinical practice....
