Introduction Cancer Immunotherapy holds great promise, but patients with excluded tumours (CD8 T cells accumulate at the tumour–stroma boundary) show increased resistance to check-point blockade compared to patients with inflamed tumours (CD8 T cells infiltrate...
Introduction A recent paper by Jacobsen et al (2023) presents data comparing whole transcriptome sequencing from fresh, frozen and formalin-fixed paraffin-embedded (FFPE) cardiac tissue. This is to investigate the effect of each storage condition on...
The epigenetic regulation of immunity and its role in inflammatory disease has become a growing focus of research over the last few years. Much of this work has investigated chromatin modification and its impact on...
Given the highly dynamic state of the environment which gives rise to tumorigenic growth, it is highly desirable to characterise not only the promoters of said growth but to also decipher the genetic conditions required...
