Introduction In this article, the authors highlight the importance of miRNAs and present the existing evidence of their relationship with lung cancer. miRNA molecules regulate gene expression and play a critical role not only as...
Introduction Crohn’s disease (CD) is a chronic condition characterised by intestinal inflammation that progressively leads to bowel destruction involving fistulas and stricturing fibrosis, along with other extra-intestinal complications. Disease triggers are likely to be multifactorial,...
Introduction Nenclares et al (2024) utilise a combinational approach to monitor the effect of chemoradiotherapy (CRT) on peripheral T-Cell receptors (TCR). CRT is a gold standard treatment for HPV-related tumour progression such as that noted...
Introduction Organoids model important aspects of human physiology and play an important role in drug discovery. However, to date, they have been lacking a tissue-specific immune compartment. The intestinal mucosal immune system is the largest...
Introduction Chen et all (2023) present a multi-omics approach characterising mechanisms of advanced Renal Cell Carcinoma (RCC) regulated by the tumour microenvironment (TME). Spatial assessment of the TME in primary and metastatic RCC conducted using...
Introduction Prostate cancer (PCa) is a heterogeneous disease, its recurrence and development of metastasis remain clinical problems. Taghreed et al. (2023) combined scRNAseq and spatial transcriptomic analyses to enhance the understanding of PCa. The data...
Introduction Cancer Immunotherapy holds great promise, but patients with excluded tumours (CD8 T cells accumulate at the tumour–stroma boundary) show increased resistance to check-point blockade compared to patients with inflamed tumours (CD8 T cells infiltrate...
Introduction A recent paper by Jacobsen et al (2023) presents data comparing whole transcriptome sequencing from fresh, frozen and formalin-fixed paraffin-embedded (FFPE) cardiac tissue. This is to investigate the effect of each storage condition on...
The epigenetic regulation of immunity and its role in inflammatory disease has become a growing focus of research over the last few years. Much of this work has investigated chromatin modification and its impact on...
Given the highly dynamic state of the environment which gives rise to tumorigenic growth, it is highly desirable to characterise not only the promoters of said growth but to also decipher the genetic conditions required...
