Introduction Colorectal cancer (CRC) has a high incidence and high mortality rate, despite surgery and chemotherapeutic treatment options. EGFR-targeted therapies, used to treat RAS WT CRC patients, are still only 55-65% effective suggesting other mechanisms...
Introduction Advanced melanoma remains a highly aggressive malignancy in which immune checkpoint inhibitors (ICIs) have transformed patient outcomes, yet resistance and heterogeneous treatment responses persist. Many clinical assays rely either on tumour informed strategies requiring...
Introduction Dai et al (2025) deployed a multi-faceted approach to investigate the mechanisms controlling Latent Endometrial Tuberculosis (LETB). LETB damages endometrial structure and function, undermining implantation and increasing infertility risk. LETB can be asymptomatic and...
Introduction In this article, the authors highlight the importance of miRNAs and present the existing evidence of their relationship with lung cancer. miRNA molecules regulate gene expression and play a critical role not only as...
Introduction Crohn’s disease (CD) is a chronic condition characterised by intestinal inflammation that progressively leads to bowel destruction involving fistulas and stricturing fibrosis, along with other extra-intestinal complications. Disease triggers are likely to be multifactorial,...
Introduction Nenclares et al (2024) utilise a combinational approach to monitor the effect of chemoradiotherapy (CRT) on peripheral T-Cell receptors (TCR). CRT is a gold standard treatment for HPV-related tumour progression such as that noted...
Introduction Organoids model important aspects of human physiology and play an important role in drug discovery. However, to date, they have been lacking a tissue-specific immune compartment. The intestinal mucosal immune system is the largest...
Introduction Chen et all (2023) present a multi-omics approach characterising mechanisms of advanced Renal Cell Carcinoma (RCC) regulated by the tumour microenvironment (TME). Spatial assessment of the TME in primary and metastatic RCC conducted using...
Introduction Prostate cancer (PCa) is a heterogeneous disease, its recurrence and development of metastasis remain clinical problems. Taghreed et al. (2023) combined scRNAseq and spatial transcriptomic analyses to enhance the understanding of PCa. The data...
Introduction Cancer Immunotherapy holds great promise, but patients with excluded tumours (CD8 T cells accumulate at the tumour–stroma boundary) show increased resistance to check-point blockade compared to patients with inflamed tumours (CD8 T cells infiltrate...
