Introduction TIFA was first identified more than 20 years ago as a binding protein for TRAF2/6, playing a role in pro-inflammatory signalling pathways. More recently, it has been shown to be essential for signalling by...
Introduction Androgenetic alopecia (AGA) is a genetic condition that affects areas of the scalp. Also known as pattern hair loss, males present with thinning hair in temporal areas that proceeds to the crown (male pattern...
Introduction Organoids model important aspects of human physiology and play an important role in drug discovery. However, to date, they have been lacking a tissue-specific immune compartment. The intestinal mucosal immune system is the largest...
Introduction Development of new therapeutics for chronic inflammatory conditions remains a key focus of pre-clinical and clinical research. In a new publication, scientists from the University of Ljubljana show that an abdominally-implanted, ultrasound-activated cellular device...
Introduction Macrophage dysregulation is implicated in inflammatory bowel disease. In this study, the upregulation of the transcription factor E4BP4 in macrophages reduced colitis severity in mice. RNA-seq and single-cell analyses showed that increased levels of...
Introduction Dysregulated immunity in the intestine can result in the establishment of Inflammatory Bowel Disease (i.e. Crohn's disease and Ulcerative Colitis). This, in turn, can increase an individual's cancer risk. Elucidating the homeostatic mechanisms that...
Introduction Prostate cancer (PCa) is a heterogeneous disease, its recurrence and development of metastasis remain clinical problems. Taghreed et al. (2023) combined scRNAseq and spatial transcriptomic analyses to enhance the understanding of PCa. The data...
Introduction The loss of epithelial barrier function is a hallmark of IBD. TNFα is considered a key driver of IBD, directly causing barrier disfunction. Although TNFα-neutralizing therapy has been used for decades to treat IBD,...
Introduction Despite large scale technological and data-driven advances, efficacious and long-lasting treatments for chronic gut illnesses such as IBD, Crohn’s and Ulcerative Colitis (UC) appear to remain out of reach for the millions of sufferers...
Currently uncurable, Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders. Characterised by progressive loss of dopaminergic neurons in the Substantia Nigra area in the brain, PD leads to the development of progressive...
