Introduction The loss of epithelial barrier function is a hallmark of IBD. TNFα is considered a key driver of IBD, directly causing barrier disfunction. Although TNFα-neutralizing therapy has been used for decades to treat IBD,...
Introduction Despite large scale technological and data-driven advances, efficacious and long-lasting treatments for chronic gut illnesses such as IBD, Crohn’s and Ulcerative Colitis (UC) appear to remain out of reach for the millions of sufferers...
Currently uncurable, Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders. Characterised by progressive loss of dopaminergic neurons in the Substantia Nigra area in the brain, PD leads to the development of progressive...
The relationship between dysbiosis, inflammation and disease is a burgeoning area of research [reviewed in 1-4]. A recently published paper by Sinha and colleagues examines the role of dysbiosis in Ulcerative Colitis[5]. Their work highlights...
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissue in culture to study tissue biology and their use for biomedical applications. Liver organoids have now been established for multiple species from induced pluripotent...
The basis of maintaining a healthy gut is the tripartite communication between the intestinal epithelium, the mucosal immune system, and the intestinal microbiome. It is important to maintain conditions that allow appropriate responses by the...
