The liver connects the intestinal portal vasculature with the general circulation. It consists of hexagonal units called lobules that not only ensure efficient metabolism but also organize immune cells in a strategic topographical distribution. The...
Kidney fibrosis is the hallmark of chronic kidney disease (CKD) progression; however, no current antifibrotic therapies exist due to the intricate cellular mechanisms involved in fibrosis and the origin of scar-forming cells in human kidney...
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissue in culture to study tissue biology and their use for biomedical applications. Liver organoids have now been established for multiple species from induced pluripotent...
The basis of maintaining a healthy gut is the tripartite communication between the intestinal epithelium, the mucosal immune system, and the intestinal microbiome. It is important to maintain conditions that allow appropriate responses by the...
