Introduction Organoid cultures offer diverse research opportunities, from studying organ development, mimicking biological processes, assessing drug toxicity and creating experimental models. The complexity and heterogeneity of organoid models demands gene expression analysis to identify global...
Introduction Organoids model important aspects of human physiology and play an important role in drug discovery. However, to date, they have been lacking a tissue-specific immune compartment. The intestinal mucosal immune system is the largest...
Introduction Chemotherapy relies on a high ratio of toxicity toward cancer cells vs. non-malignant cells. Normal tissues with a high proportion of proliferating cells such as the epithelia of the gut, are most vulnerable toward...
Introduction Despite large scale technological and data-driven advances, efficacious and long-lasting treatments for chronic gut illnesses such as IBD, Crohn’s and Ulcerative Colitis (UC) appear to remain out of reach for the millions of sufferers...
The intestinal epithelium is characterised by intense self-renewal which is accomplished by intestinal stem cells (ISCs), located at the base of the crypts. Beyond normal tissue homeostasis, these cells play a major role in the...
