Introduction Crohn’s disease (CD) is characterised by relapsing inflammation that recurs in the same regional locations within the intestine. This suggests that permanent or long-lasting, molecular changes are occurring at the cellular level. Epigenetic modifications...
Introduction N-acetyltransferase2 (NAT2) is a phase II drug metabolic enzyme with many reported SNPs that affect its catalytic activity. Depending upon the combination of alleles present a subject could have slow, intermediate or rapid acetylator...
Introduction TIFA was first identified more than 20 years ago as a binding protein for TRAF2/6, playing a role in pro-inflammatory signalling pathways. More recently, it has been shown to be essential for signalling by...
Introduction The gut microbiota is now recognised as a central player in the pathogenesis and progression of inflammatory bowel disease (IBD). In their recent study, Wang et al examine how disruptions in microbial composition can...
Introduction Organoid cultures offer diverse research opportunities, from studying organ development, mimicking biological processes, assessing drug toxicity and creating experimental models. The complexity and heterogeneity of organoid models demands gene expression analysis to identify global...
Introduction Caldwell et al., present an approach to the targeted selection of suitable candidate patients into a phase 2 clinical study using a laboratory validated chromogenic RNAscope assay for DKK1. Dickkopf-1 (DKK1), is a secreted...
Introduction Male-pattern hair loss (MPHL), also known as androgenic alopecia (AGA), is a progressive condition caused by circulating androgens, oxidative stress, the scalp microbiome and genetic factors. The only effective treatments available for MPHL are...
Introduction In this article, the authors highlight the importance of miRNAs and present the existing evidence of their relationship with lung cancer. miRNA molecules regulate gene expression and play a critical role not only as...
Introduction Androgenetic alopecia (AGA) is a genetic condition that affects areas of the scalp. Also known as pattern hair loss, males present with thinning hair in temporal areas that proceeds to the crown (male pattern...
Introduction Marano et al., describe a method to combine RNAscope with immunohistochemistry to achieve double labelling of perforin transcripts within CD8+ or TcRγδ intraepithelial lymphocytes in small intestine sections of celiac disease patients. One aspect...
