Introduction Androgenetic alopecia (AGA) is a genetic condition that affects areas of the scalp. Also known as pattern hair loss, males present with thinning hair in temporal areas that proceeds to the crown (male pattern...
Introduction Marano et al., describe a method to combine RNAscope with immunohistochemistry to achieve double labelling of perforin transcripts within CD8+ or TcRγδ intraepithelial lymphocytes in small intestine sections of celiac disease patients. One aspect...
Introduction Development of new therapeutics for chronic inflammatory conditions remains a key focus of pre-clinical and clinical research. In a new publication, scientists from the University of Ljubljana show that an abdominally-implanted, ultrasound-activated cellular device...
Introduction Sande et al. conducted a comprehensive evaluation of the clinical utility of the HRM-based HemeScreen MPN assay as a generic diagnostic approach for Philadelphia-negative myeloproliferative neoplasms (MPNs). The majority of mutations identified in MPNs...
Introduction Macrophage dysregulation is implicated in inflammatory bowel disease. In this study, the upregulation of the transcription factor E4BP4 in macrophages reduced colitis severity in mice. RNA-seq and single-cell analyses showed that increased levels of...
Introduction Prostate cancer (PCa) is a heterogeneous disease, its recurrence and development of metastasis remain clinical problems. Taghreed et al. (2023) combined scRNAseq and spatial transcriptomic analyses to enhance the understanding of PCa. The data...
Introduction A recent paper by Jacobsen et al (2023) presents data comparing whole transcriptome sequencing from fresh, frozen and formalin-fixed paraffin-embedded (FFPE) cardiac tissue. This is to investigate the effect of each storage condition on...
The epigenetic regulation of immunity and its role in inflammatory disease has become a growing focus of research over the last few years. Much of this work has investigated chromatin modification and its impact on...
Given the highly dynamic state of the environment which gives rise to tumorigenic growth, it is highly desirable to characterise not only the promoters of said growth but to also decipher the genetic conditions required...
Currently uncurable, Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders. Characterised by progressive loss of dopaminergic neurons in the Substantia Nigra area in the brain, PD leads to the development of progressive...
