Introduction A study published by Li et al. in Scientific Data (Nature), in 2025 detailed comprehensive molecular characterisation of chronic colitis in interleukin-10–deficient (IL-10⁻/⁻) mice, a model widely recognised for its relevance to Crohn’s disease-like...
Introduction Epithelial regeneration in inflammatory bowel disease (IBD) is governed by complex interactions between intestinal epithelial cells and their surrounding microenvironment. The mechanism by which this occurs is poorly understood, and the influence of these...
Introduction Colorectal cancer (CRC) has a high incidence and high mortality rate, despite surgery and chemotherapeutic treatment options. EGFR-targeted therapies, used to treat RAS WT CRC patients, are still only 55-65% effective suggesting other mechanisms...
Introduction Hair growth progresses through a series of cycle phases, anagen, catagen and telogen. Dysregulation of these cycles can lead to alopecia. There are currently few potent therapies available to treat hair loss. Cycling of...
Introduction Advanced melanoma remains a highly aggressive malignancy in which immune checkpoint inhibitors (ICIs) have transformed patient outcomes, yet resistance and heterogeneous treatment responses persist. Many clinical assays rely either on tumour informed strategies requiring...
Introduction Dai et al (2025) deployed a multi-faceted approach to investigate the mechanisms controlling Latent Endometrial Tuberculosis (LETB). LETB damages endometrial structure and function, undermining implantation and increasing infertility risk. LETB can be asymptomatic and...
Introduction Crohn’s disease (CD) is characterised by relapsing inflammation that recurs in the same regional locations within the intestine. This suggests that permanent or long-lasting, molecular changes are occurring at the cellular level. Epigenetic modifications...
Introduction Alopecia areata (AA) is the most common inflammatory hair disease. Current therapies do not suppress disease reoccurance. Interferon gamma (IFNg) is a key pathogenic cytokine that drives AA. Interleukin 15 (IL-15) can activate IFNg...
Introduction Breast cancer survival rates have improved over the decades, but one-third of diagnoses still result in death. Therefore, identifying novel molecular targets is crucial. Hypoxia, common in breast tumors, is linked to tumor progression,...
Introduction Male-pattern hair loss (MPHL), also known as androgenic alopecia (AGA), is a progressive condition caused by circulating androgens, oxidative stress, the scalp microbiome and genetic factors. The only effective treatments available for MPHL are...
