Introduction Breast cancer survival rates have improved over the decades, but one-third of diagnoses still result in death. Therefore, identifying novel molecular targets is crucial. Hypoxia, common in breast tumors, is linked to tumor progression,...
Introduction Caldwell et al., present an approach to the targeted selection of suitable candidate patients into a phase 2 clinical study using a laboratory validated chromogenic RNAscope assay for DKK1. Dickkopf-1 (DKK1), is a secreted...
Introduction Nenclares et al (2024) utilise a combinational approach to monitor the effect of chemoradiotherapy (CRT) on peripheral T-Cell receptors (TCR). CRT is a gold standard treatment for HPV-related tumour progression such as that noted...
Introduction Sande et al. conducted a comprehensive evaluation of the clinical utility of the HRM-based HemeScreen MPN assay as a generic diagnostic approach for Philadelphia-negative myeloproliferative neoplasms (MPNs). The majority of mutations identified in MPNs...
Given the highly dynamic state of the environment which gives rise to tumorigenic growth, it is highly desirable to characterise not only the promoters of said growth but to also decipher the genetic conditions required...
Currently uncurable, Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders. Characterised by progressive loss of dopaminergic neurons in the Substantia Nigra area in the brain, PD leads to the development of progressive...
