Acute In Vivo Models
Epistem offers acute excisional and incisional wounding models.
Chronic In Vivo Models
Pathological and physiological conditions may give rise to delays in the wound healing process, resulting in the formation of chronic wounds. Epistem can offer a variety of chronic wound models, including diabetes-impaired wound healing, delayed wound healing caused by oestrogen deficiency and infection-delayed wound healing.
The models available allow a range of healing endpoints to be measured, such as wound closure, re-epithelialisation, angiogenesis, granulation tissue maturity, collagen deposition and inflammatory response.
- Wound closure and degree of scarring
- Histology and immunohistochemistry
- Image analysis (Aperio® ScanScope®)
- Cytokine profiling
- Gene expression