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Gastrointestinal Mucositis Models

Providing physiological and histopathological evaluations of disease severity which can be used to determine the mechanism of action of a novel therapeutic agent and to define the optimum dosing regimen.

To mimic a clinically relevant insult, total or partial-body irradiation and chemotherapy agents can be administered.
The crypt cells affected by many chemotherapy agents are well characterised; the effects of novel mucositis agents on these cell populations can therefore be measured. This knowledge also enables the clinical consequences of novel oncology agents to be predicted.

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An Overview

Evaluating the Effects of Cytotoxic Insult and Mucositis

Gastrointestinal Mucositis is a dangerous condition which arises from a variety of causes, including radiation therapy, chemotherapy and certain infections. The resulting inflammation and damage can lead to a range of symptoms, including diarrhoea, ulcers and abdominal pain. Understanding the effects of cytotoxic insult and mucositis is important in order to develop effective treatments and to minimise the risk of complications.

Model Description

The cytotoxic insult is administered and mucositis gradually develops. The effects on apoptosis and cell proliferation in a given cell population can be quantified within hours of irradiation. The effect on ulceration and diarrhoea severity can be quantified over the following days.

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