Gastrointestinal Mucositis is a dangerous condition which arises from a variety of causes, including radiation therapy, chemotherapy and certain infections. The resulting inflammation and damage can lead to a range of symptoms, including diarrhoea, ulcers and abdominal pain. Understanding the effects of cytotoxic insult and mucositis is important in order to develop effective treatments and to minimise the risk of complications.
The cytotoxic insult is administered and mucositis gradually develops. The effects on apoptosis and cell proliferation in a given cell population can be quantified within hours of irradiation. The effect on ulceration and diarrhoea severity can be quantified over the following days.
- Diarrhoea duration and severity
- Histology and immunohistochemistry
- Crypt survival
- Apoptosis and proliferation
- Multiplex analysis of inflammatory cytokines
Bespoke readouts available. Please contact us for more information.