Skip to content

GI Toxicity

Models To Investigate the GI Side Effects of Potential Therapeutics

GI toxicity manifests as hypo / hyperplasias (frequent villus atrophy), erosions and abscesses, Goblet cell hyperplasias, inflammatory infiltrates etc. In addition to pathologies, there may be digestive changes, perturbed barrier function and shifts in the microbiome.

Why GI Toxicity?

There are a number of assays that can be employed depending on the risk of toxicity/observed toxicities.

Epistem’s Models for Assessing Gastrointestinal Toxicity

In vitro models derived from primary tissue (such as organoids or organoid derived monolayers) can be early screens for toxic potential, and also identify potential mechanisms such as changes in permeability.

In vivo models can uncover physiological and pathological changes, identify the target cell population and modified pathways. Since the GI epithelium is constantly being replaced the timings within such assays is crucial.

Download the latest brochure

From brochures to posters, find all the information you need in a downloadable & printable format.

Contact information

For more information regarding our services, please do not hesitate to contact us.

Contact us