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Acute Radiation Syndrome (ARS)

Evaluation of Radiation Induced Toxicity Within the First Month of Exposure

Replicating the radiation damage to the intestine and bone marrow experienced by people exposed to high dose irradiation, the Epistem models evaluate whether outcomes can be improved by pre or post irradiation treatment. Outcome and histopathology can be compared and linked to PK data.

Why ARS?

Radiation damage to the intestine and bone marrow can be lethal. The Epistem models evaluate whether the damage can be reduced by pre or post irradiation treatment. Histopathological assessments can be performed in several species linking PK and PD data.

Gastrointestinal – Acute Radiation Syndrome

Radiation kills the rapidly proliferating clonogenic cells in intestinal crypts. If all the clonogenic cells are killed, the crypt will die. If sufficient crypts die, ulcers will form, resulting in diarrhoea, infection, dehydration, and death.


Haematopoietic – Acute Radiation Syndrome

The effects of H-ARS manifest later than GI-ARS, however, the bone marrow is highly sensitive. A lower dose of irradiation is therefore required and detrimental effects manifest over a longer time course than GI-ARS (apparent from day 10 onwards).

Readouts Include

  • Survival
  • Diarrhoea duration and severity
  • Crypt survival and regeneration
  • Apoptosis and proliferation
  • Histology / IHC and image analysis
  • Flow cytometry
  • Protein / Gene expression (including specific areas using lase capture microscopy)
  • Cytokine profiling

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