Assessing Tissue with Limited Quantities or Low Quality RNA
We have utilised this technology to provide pharmacogenomic information from:
- Single cells
- Plucked scalp hair (mouse, rat, dog, primate and human)
- Laser capture microdissected (LCM) tissue
- Fractionated blood cell populations (PBMCs)
- Preclinical and clinical biopsies (in oncology and inflammatory diseases)
- FFPE tissue sections and curls
We are also able to provide extensive gene expression information from our proprietary database containing information that we have compiled from healthy normal volunteer samples and our own data from clinical and preclinical studies.
Using this information, we can quickly recommend the appropriate tissue or sample to monitor drug response.
Gene Expression Disease Panels
- Oncology Panels
- Inflammatory Bowel Disease Panels
- Hair Panels
- Fibrosis Panels
Data Analysis
Epistem recognises the significance of analysing next-generation sequencing (NGS) data and therefore provides personalised bioinformatic analysis services to meet your research requirements.
Our team of experts can conduct unbiased interrogation of genes that are differentially expressed between relevant comparison groups, followed by comprehensive statistical analysis based on group experimental factors. We also specialise in focused analysis of genes or pathways of interest.
We specialise in deciphering gene expression information to obtain gene expression biomarker signatures that are relevant to specific compounds, which can be used in clinical settings to monitor drug target engagement and treatment progression.
Analysis may include demultiplexing of samples and raw data QC, genome alignment, identification of differentially expressed genes, pathway analysis and biomarker signature identification and assessment. Where relevant public datasets are available, signature biomarkers can be assessed in independent studies.
Contact us today to learn more about how we can help you achieve your research goals.
Gene Expression Services available:
- Next Generation Sequencing
- Microarray Analysis
- qPCR Analysis
